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Labs/MECP2
Labs/MECP2
19-run Rett MBD–DNA campaign. InterfaceAnneal seats R106W and R133C. Engine abstract: 15 CONFIRMED, 1 DEVIATION, 3 INDETERMINATE. GitHub-only, Aug 2025.
Strongest claim
Interface-focused anneal yielded near-native MBD–DNA complexes for two Rett mutations in this coarse-grained model. Deterministic half independently reproduced 15/1/3 including Run 5 DEVIATION.
Boundary
Not a Rett therapy. Run 5 is a recorded DEVIATION (contracted RMSD ≥ 20 Å, data 3.06 Å). Runs 1–3 INDETERMINATE. PNG/PDB are Git LFS.
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