Restricted · applied
Labs/p53
Labs/p53
12-run coarse-grained p53 DBD campaign. R248Q electrostatic failure vs Y220C kinetic trap. Contact-anneal + PhiKan083 improved Y220C inside this force field. GitHub-only, Aug 2025.
Strongest claim
Distinct misfolding mechanisms at similar final RMSD; genetic pocket patches fail; a protocol-level anneal improved Y220C relative to ~25 Å baselines.
Boundary
Not native folding. WT also misfolds to 26.6 Å. Not a cancer therapy. This compile: 11 CONFIRMED, Run 9 INDETERMINATE (ContactAnneal folder missing). PNG/PDB are Git LFS.
Wiki